You could probably solve this by removing the Run.GPS data directory (/sdcard/My Documents/Run.GPS).
What is the error message?
What is your software version? Build number?
Can you send the first 2 lines of the detailed error message? (like a.ce() de.f())
I did a hard reset of my HTC touch 3G smartphone, reinstalled the latest version of run.GPS.
I was surprised to see that my user config was still there which I was nice but I get an error when I try to open my training history. This also stops me from uploading new trainings.